The Potential Role of Melatonin on Mental Disorders: Insights from Physiology and Pharmacology

Back Ground: Mental diseases have become common in modern society, which seriously harm the human health. The etiology of mental diseases is complex, general theories and methods of mechanism and prevention guidance of mental diseases cannot fully explain the clinical hysteresis effects of antipsychotic and antineuropathy drugs. Methods: In this review, we summarize recent advances in melatonin research, focusing on the mental diseases with special emphasis on the alterations of melatonin secretion and the associated changes in biological rhythms of disorders. Results: With the results from biochemical measurements in melatonin treatment of mental disorders, including anxiety, depression, schizophrenia, autism and attention deficit hyperactivity disorder, showed that melatonin treatment of mental disorders did not have serious negative consequences melatonin will likely be widely used in the treatment of mental disorders in clinical practice. At the same time, the measurements of the effects of melatonin treatments would become more standardized and effective. Conclusion: In the future, there would be a breakthrough progress in the treatment of mental disorders field by using melatonin. The potential role of melatonin on mental disorders would be attached great importance by related disciplines. *Corresponding author: Lin sun, Department of Psychology, Weifang Medical University, 7166# Baotong West Street, Weifang Shandong, 261053, P. R. China, Tel: +86-18369695811; E-mail: [email protected] Received December 16, 2015; Accepted February 23, 2016; Published February 29, 2016 Citation: Sun X, Wang Y, Jiang N, Du Z, Sun H, et al. (2016) The Potential Role of Melatonin on Mental Disorders: Insights from Physiology and Pharmacology. Bipolar Disord 2: 105. doi:10.4172/jbd.1000105 Copyright: © 2016 Sun X, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. The Potential Role of Melatonin on Mental Disorders: Insights from Physiology and Pharmacology Xiaoran Sun1, Yani Wang2, Nengzhi Jiang1, Zhongde Du3, Hongwei Sun1, Lin Sun1* 1Department of Psychology, Weifang Medical University, 7166# Baotong West Street, Weifang Shandong, 261053, P. R. China 2Department of Foreign languages, Weifang Medical University, 7166# Baotong West Street, Weifang Shandong, 261053, P. R. China 3Department of Neurology, Chinese People's Liberation Army eighty-nine Hospital, 256# Beigong West Street, Weifang, Shandong, 261021, P. R. China